SDCSB began in 2005 as the San Diego Consortium for Systems Biology to bring together scientists across disciplines and institutions, promote collaborative research and training, and to support the exchange of ideas and resources.

NCSB LogoIn 2010, we became one of the National Centers for Systems Biology funded by the National Institute of General Medical Sciences (NIGMS) (Grant #GM085764). SDCSB comprises activities in (i) scientific research, (ii) scientific outreach, and (iii) educational outreach.

We welcome you to participate in the revolution that is gripping the biological and biomedical sciences, catalyzed by unprecedented measurement capabilities and computational analysis and modeling tools. Start by exploring this website, participate in our workshops, symposia and research meetings, and let us know about good ideas for new research and outreach activities that SDCSB can support.

Pulsing Signals Help to Overcome Noise

Pulsing Signals crop BBiological systems must transmit information in the face of both intrinsic noise inherent to biochemical reactions and extrinsic noise due to cell-to-cell variations. Using both experimental and theoretical approaches to, researchers in Roy Wollman’s group found that pulsed signals are more reliable at overcoming the effects of cell-to-cell variability that than just a single, one-off signal. 

Read in Science
Mutations in p53 Alone Don’t Explain Deadly Cancer

TP53-3p Survival Curves 2

Although mutations in p53 are associated with more aggressive forms of cancer, researchers in Trey Ideker’s lab have found evidence suggesting that the deleterious effects of the mutated gene may in large part be due to other genetic abnormalities, at least in squamous cell head and neck cancers. In a study published in Nature Genetics,  researchers found that the high mortality rates among head and neck cancer patients tends only to occur when mutations in p53 coincide with the loss of the short arm of chromosome 3.

Read in Nature Genetics
Using gene position to test the “histone code”

ideker2012In a novel use of gene knockout technology, researchers at the University of California, San Diego School of Medicine tested the same gene inserted into 90 different locations in a yeast chromosome – and discovered that while the inserted gene never altered its surrounding chromatin landscape, differences in that immediate landscape measurably affected gene activity.

Read in Cell Reports (2013)

SDCSB Director, Dr. Ideker, named AAAS Fellow

December 4, 2014

Trey Ideker, a professor at UC San Diego’s School of Medicine, was cited by AAAS for “distinguished contributions to the fields of bioinformatics and computational biology, particularly in pioneering network research.” His research seeks to comprehensively map connections between the ...

Systems analysis of host-pathogen interactions

November 6, 2014

January 7, 2015 8:00am-5:00pm The Salk Institute for Biological Studies

In collaboration with SDCSB, the NIAID-funded FluOMICS and FluDyNeMo Programs is pleased to announce that registration and poster abstract submission for the 1st Annual Systems Biology and Host-Pathogen Interactions Symposium is now ...

Systems-to-Synthesis Symposium – May 2, 2014

April 24, 2014

**Congratulations to Speakers selected from the submitted abstracts to deliver a 15mn talk** Anne-Ruxandra Carvunis, Ph.D.

UC San Diego, Medicine (Trey Ideker lab) “On the illusion of evolutionary divergence in regulatory networks”; Guan Ning Lin, Ph.D.

UC San Diego, Psychiatry (Lilia Iakoucheva lab) “Interaction ...

Previous SDCSB News

Conferences and Workshops

Metabolomics Workshop
March 27, 2015
Sanford Consortium for Regenerative Medicine
Systems-to-Synthesis Quarterly Research Meetings
April 10, 2015
The Village 15th Floor
Cytoscape and Network Analysis Workshop
April 17, 2015
Sanford Consortium for Regenerative Medicine
Math Modeling Tutorial Workshop
April 20, 2015 - April 25, 2015
UCSD Bonner Hall (Room 2130)
Organized by Lev Tsimring
Click here to register
Intellectual Property and Licensing Workshop
April 24, 2015
Sanford Consortium for Regenerative Medicine
Organized by Kamala Janiyani
Click here to register
Next Generation Sequencing Workshop
May 1, 2015
Sanford Consortium for Regenerative Medicine

Weekly Events

Genetics, Bioinformatics and Systems Biology Colloquium (2014-15)

Joint BCI / SDCSB Seminar Series (2014 Fall)

Greatest Hits of Systems Biology Journal Club (2014 Winter)