SDCSB began in 2005 as the San Diego Consortium for Systems Biology to bring together scientists across disciplines and institutions, to promote collaborative research and training, and to support the exchange of ideas and resources.

NCSB LogoIn 2010, we became one of the National Centers for Systems Biology funded by the National Institute of General Medical Sciences (NIGMS) (P50 GM085764). Over the past five years our research has led to significant systems biology advances, including genome-wide studies of how stress remodels transcriptional and genetic networks, discovery of an independent metabolic clock coordinating cell growth through cycles of TOR1 activity, demonstration that much of the Gene Ontology can be inferred directly from ‘omics data, prediction of cancer survival time and drug response by an approach called Network Based Stratification and a series of major feats in engineering of synthetic coupled genetic circuits.

The theme of our Center – “From Maps to Models” – addresses an important challenge in systems biology: traversing between network maps and mathematical models, two very successful but so far mostly separate biological representations and modes of study. Network maps tend to be global, static, abstract and descriptive, whereas mathematical models tend to be local, dynamic, detailed and predictive. Guided by this overarching theme, four SDCSB research projects seek to develop a general library of maps and models relevant to fundamental cellular and super-cellular processes, including the spatiotemporal architecture of the genome, protein turnover dynamics, cell-cell communication and heterogeneity and environment-genome interactions. These mapping and modeling activities are fueled by technologies advanced across three SDCSB core platforms.

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Competition and Cooperation in Biofilms

Gurol's Ode to Target

Gurol Suel’s lab recently found that bacterial biofilms grow in pulses, with the bacteria on the outer edge temporarily slowing their growth rate to allow the bacteria in the center more access to nutrients. Perhaps then one way to control these largely antibiotic resistant biofilms is to disrupt the underlying communication signals leading to runaway growth on the edge and eventual collapse of the entire community.

Read in Nature


PQBP1 triggers innate immue responses to HIV-1

The innate immune response to HIV-1 is in part coordinated by dendritic cells, immune sentinels that themselves are targets of HIV-1 infection. Sumit Chanda’s lab recently discovered that immunogenic HIV-1 reverse transcripts are recognized in dendritic cells by PQBP1, which then initiates the innate immune response.

Read in Cell

Pulsing Signals Help to Overcome Noise

Pulsing Signals crop BBiological systems must transmit information in the face of both intrinsic noise inherent to biochemical reactions and extrinsic noise due to cell-to-cell variations. Using both experimental and theoretical approaches to, researchers in Roy Wollman’s group found that pulsed signals are more reliable at overcoming the effects of cell-to-cell variability that than just a single, one-off signal. 

Read in Science

Cells, Sensors and Systems Symposium

September 23, 2015

Thursday, October 22, 2015, from 10 am to 5 pm Sanford Consortium For Regenerative Medicine

Co-Chairs: Jeffrey H. Price (SBP and Scintillon Institute) and John P. Nolan (Scintillon Institute) Chair Emeritus and Program Advisor: Robert F. Murphy (Carnegie Mellon University)

Program Committee: Mark Mercola ...

Curt Becker, Founder of Applied Biosystems, at the Fleet Center’s Suds and Science

September 8, 2015

As part of the Fleet Science Center’s Suds and Science Program, Curt Becker will present “Genetic Engineering—Can It Be the Solution to the World’s Problems?”

September 14, 2014, from 6:30 p.m. to about 8 p.m.

Stone Brewing World Bistro & Gardens – ...

Winter q-Bio Meeting

September 1, 2015

The Winter q-bio meeting welcomes scientists and engineers who are interested in all areas of q-bio. For 2016, the meeting will be held on the island of Oahu, at the Sheraton Waikiki, from February 14-18. More information can be found at ...
Previous SDCSB News

Conferences and Workshops

San Diego Bioinformatics Users Series (SDBUS)
4:00 pm - 6:00 pm, October 7, 2015
UCSD - BRF2, room 2A03
Register for the event here
Quarterly Systems-to-Synthesis Meeting
1:30 pm - 6:00 pm, October 8, 2015
Meeting Rooms on Fifteen, Building 1, Village West
Register for the event here
Cells, Sensors and Systems Symposium
10:00 am - 5:00 pm, October 22, 2015
Sanford Consortium For Regenerative Medicine
Organized by Prof. Mark Mercola, UCSD
Click here for more information
Annual Scientific Retreat
January 29, 2016 - January 31, 2016
UCLA Lake Arrowhead Conference Center
Registration begins in the fall
Metabolomics Conference
1:30 pm - 6:00 pm, February 19, 2016
Sanford Consortium for Regenerative Medicine
Organized by Asst. Prof. Mohit Jain, UCSD
Registration begins in late 2015
Intellectual Property and Licensing Workshop
1:30 pm - 6:00 pm, March 24, 2016
Sanford Consortium for Regenerative Medicine
Organized by Kamala Janiyani, UCSD
Registration begins in early 2016
Quarterly Systems-to-Synthesis Meeting
1:30 pm - 6:00 pm, April 14, 2016
Meeting Rooms on Fifteen, Building 1, Village West
Registration begins in early 2016
Cytoscape Workshop
1:30 pm - 6:00 pm, May 19, 2016
Sanford Consortium for Regenerative Medicine
Organized by Dr. Barry Demchak, UCSD
Registration begins in early 2016

Weekly Events

Genetics, Bioinformatics and Systems Biology Colloquium (2014-15)

Joint BCI / SDCSB Seminar Series (2014 Fall)

Greatest Hits of Systems Biology Journal Club (2014 Winter)