SDCSB began in 2005 as the San Diego Consortium for Systems Biology to bring together scientists across disciplines and institutions, promote collaborative research and training, and to support the exchange of ideas and resources.

NCSB LogoIn 2010, we became one of the National Centers for Systems Biology funded by the National Institute of General Medical Sciences (NIGMS) (Grant #GM085764). SDCSB comprises activities in (i) scientific research, (ii) scientific outreach, and (iii) educational outreach.

We welcome you to participate in the revolution that is gripping the biological and biomedical sciences, catalyzed by unprecedented measurement capabilities and computational analysis and modeling tools. Start by exploring this website, participate in our workshops, symposia and research meetings, and let us know about good ideas for new research and outreach activities that SDCSB can support.

SDCSB Directors,
Trey Ideker
Alexander Hoffmann
Jeff Hasty

Mutations in p53 Alone Don’t Explain Deadly Cancer

TP53-3p Survival Curves 2

Although mutations in p53 are associated with more aggressive forms of cancer, researchers in Trey Ideker’s lab have found evidence suggesting that the deleterious effects of the mutated gene may in large part be due to other genetic abnormalities, at least in squamous cell head and neck cancers. In a study published in Nature Genetics,  researchers found that the high mortality rates among head and neck cancer patients tends only to occur when mutations in p53 coincide with the loss of the short arm of chromosome 3.

Read in Nature Genetics
Using gene position to test the “histone code”

ideker2012In a novel use of gene knockout technology, researchers at the University of California, San Diego School of Medicine tested the same gene inserted into 90 different locations in a yeast chromosome – and discovered that while the inserted gene never altered its surrounding chromatin landscape, differences in that immediate landscape measurably affected gene activity.

Read in Cell Reports (2013)

Systems analysis of host-pathogen interactions

November 6, 2014

January 7, 2015 8:00am-5:00pm The Salk Institute for Biological Studies

In collaboration with SDCSB, the NIAID-funded FluOMICS and FluDyNeMo Programs is pleased to announce that registration and poster abstract submission for the 1st Annual Systems Biology and Host-Pathogen Interactions Symposium is now ...

Systems-to-Synthesis Symposium – May 2, 2014

April 24, 2014

**Congratulations to Speakers selected from the submitted abstracts to deliver a 15mn talk** Anne-Ruxandra Carvunis, Ph.D.

UC San Diego, Medicine (Trey Ideker lab) “On the illusion of evolutionary divergence in regulatory networks”; Guan Ning Lin, Ph.D.

UC San Diego, Psychiatry (Lilia Iakoucheva lab) “Interaction ...

2014 San Diego Festival of Science & Engineering

March 22, 2014

Wow! What an incredible 2014 EXPO DAY at PETCO Park! Our Bioinformatics and Systems Biology graduate students delivered another outstanding and memorable day of hands-on, interactive Science, Technology, Engineering and Math (STEM) activities and entertainment to more than 23,000 participants. We had ...

Previous SDCSB News

Conferences and Events

Systems Biology of Host-Pathogen Interactions
January 7, 2015
Salk Institute for Biological Studies, La Jolla
MURI Winter School 2015
January 7, 2015 - January 10, 2015
15th Floor, Building 1, Village West, UC San Diego
SDCSB Annual Retreat
January 9, 2015 - January 12, 2015
UCLA Lake Arrowhead Conference Center
Southern California Systems Biology Conference
January 31, 2015
UC Irvine, Student Center, Crystal Cove Ballroom
Workshop on Next Gen RNA Seq Analysis
8:00 am - 12:00 pm, February 6, 2015
Sanford Consortium for Regenerative Medicine, La Jolla
The Third Annual Winter q-Bio Meeting
February 17, 2015 - February 21, 2015
The Westin Maui Resort & Spa, Hawaii
Metabolomics Workshop
March 27, 2015
Sanford Consortium for Regenerative Medicine
Workshop on Cytoscape and Network Analysis
April 17, 2015
Sanford Consortium for Regenerative Medicine
Systems-to-Synthesis Symposium
May 29, 2015
Salk Institute for Biological Studies



SDCSB Journal Club


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