SDCSB began in 2005 as the San Diego Consortium for Systems Biology to bring together scientists across disciplines and institutions, promote collaborative research and training, and to support the exchange of ideas and resources.

NCSB LogoIn 2010, we became one of the National Centers for Systems Biology funded by the National Institute of General Medical Sciences (NIGMS) (Grant #GM085764). SDCSB comprises activities in (i) scientific research, (ii) scientific outreach, and (iii) educational outreach.

We welcome you to participate in the revolution that is gripping the biological and biomedical sciences, catalyzed by unprecedented measurement capabilities and computational analysis and modeling tools. Start by exploring this website, participate in our workshops, symposia and research meetings, and let us know about good ideas for new research and outreach activities that SDCSB can support.

SDCSB Directors,
Trey Ideker
Alexander Hoffmann
Jeff Hasty

Mutations in p53 Alone Don’t Explain Deadly Cancer

TP53-3p Survival Curves 2

Although mutations in p53 are associated with more aggressive forms of cancer, researchers in Trey Ideker’s lab have found evidence suggesting that the deleterious effects of the mutated gene may in large part be due to other genetic abnormalities, at least in squamous cell head and neck cancers. In a study published in Nature Genetics,  researchers found that the high mortality rates among head and neck cancer patients tends only to occur when mutations in p53 coincide with the loss of the short arm of chromosome 3.

Read in Nature Genetics
Using gene position to test the “histone code”

ideker2012In a novel use of gene knockout technology, researchers at the University of California, San Diego School of Medicine tested the same gene inserted into 90 different locations in a yeast chromosome – and discovered that while the inserted gene never altered its surrounding chromatin landscape, differences in that immediate landscape measurably affected gene activity.

Read in Cell Reports (2013)

Systems-to-Synthesis Symposium – May 2, 2014

April 24, 2014

**Congratulations to Speakers selected from the submitted abstracts to deliver a 15mn talk** Anne-Ruxandra Carvunis, Ph.D.

UC San Diego, Medicine (Trey Ideker lab) “On the illusion of evolutionary divergence in regulatory networks”; Guan Ning Lin, Ph.D.

UC San Diego, Psychiatry (Lilia Iakoucheva lab) “Interaction ...

2014 San Diego Festival of Science & Engineering

March 22, 2014

Wow! What an incredible 2014 EXPO DAY at PETCO Park! Our Bioinformatics and Systems Biology graduate students delivered another outstanding and memorable day of hands-on, interactive Science, Technology, Engineering and Math (STEM) activities and entertainment to more than 23,000 participants. We had ...

2014 qBio Summer Bootcamp

February 1, 2014

The Quantitative Biology Summer Bootcamp at UCSD and SDSU is designed to introduce motivated and curious students from any institutions in the greater San Diego area to the new leading-edge field of Quantitative Biology. Inquiries from undergraduate or graduate students, ...

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