SDCSB began in 2005 as the San Diego Consortium for Systems Biology to bring together scientists across disciplines and institutions, to promote collaborative research and training, and to support the exchange of ideas and resources.

NCSB LogoIn 2010, we became one of the National Centers for Systems Biology funded by the National Institute of General Medical Sciences (NIGMS) (P50 GM085764). Over the past five years our research has led to significant systems biology advances, including genome-wide studies of how stress remodels transcriptional and genetic networks, discovery of an independent metabolic clock coordinating cell growth through cycles of TOR1 activity, demonstration that much of the Gene Ontology can be inferred directly from ‘omics data, prediction of cancer survival time and drug response by an approach called Network Based Stratification and a series of major feats in engineering of synthetic coupled genetic circuits.

The theme of our Center – “From Maps to Models” – addresses an important challenge in systems biology: traversing between network maps and mathematical models, two very successful but so far mostly separate biological representations and modes of study. Network maps tend to be global, static, abstract and descriptive, whereas mathematical models tend to be local, dynamic, detailed and predictive. Guided by this overarching theme, four SDCSB research projects seek to develop a general library of maps and models relevant to fundamental cellular and super-cellular processes, including the spatiotemporal architecture of the genome, whole-cell proteome dynamics, cell-cell communication and heterogeneity and environment-genome interactions. These mapping and modeling activities are fueled by technologies advanced across three SDCSB core platforms.

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Translating Gentoypes to Phenotypes

CELS_COVER-1The challenge of predicting biological outcomes based on underlying genetic features has vexed biologists for decades. A recent paper from Trey Ideker and colleagues described a new approach based on machine learning that leverages prior knowledge about how cells are organized. Instead of just considering which genes are mutated, this approach takes into account how combinations of mutated genes interact with one another such as in an organelle or as joint participants in a biochemical pathway.


Read in Cell Systems
Electricity Coursing through Biofilms

The endogenous role of ion channels in bacteria has long been a mystery. Recent work from the Suel lab has revealed that ion channels allow for long-range electrical communication in bacterial biofilms. These electrical signals play a key role coordinating growth. Perhaps then one way to control the growth of these largely antibiotic resistant biofilms is to disrupt these signals leading to unregulated growth and the eventual collapse of the entire community.

Read in Nature
PQBP1 triggers innate immue responses to HIV-1

The innate immune response to HIV-1 is in part coordinated by dendritic cells, immune sentinels that themselves are targets of HIV-1 infection. Sumit Chanda’s lab recently discovered that immunogenic HIV-1 reverse transcripts are recognized in dendritic cells by PQBP1, which then initiates the innate immune response.

Read in Cell

4th Annual “Host-Pathogen Interactions: Circuits to Systems” Symposium

December 18, 2017

Tuesday, February 6, 2018 from 8:30 AM – 7:00 PM Roth Auditorium at the Sanford Consortium for Regenerative Medicine 2880 Torrey Pines Science Drive, La Jolla, CA

Participation is FREE, but registration is required for all attendees. For registration, including travel grant and poster ...

Applications Now Open For the Systems Biology Training Program

August 10, 2017

Sponsored by the San Diego Center for Systems Biology and UC San Diego Health Sciences



The San Diego Center for Systems Biology (SDCSB) is pleased to accept applications for our Systems Biology Training Program. Applications are solicited from graduate students and ...

Ensembl Tutorial

April 17, 2017

Monday, May 8, 2017, from 8:30 am – 4:30 pm Medical Education & Telemedicine Building, Room 141 Hosted by Helen Sparrow – Ensembl Outreach Officer European Bioinformatics Institute (EMBL-EBI)


Register for the event here BRING YOUR OWN LAPTOP


This full-day workshop will provide ...

Previous SDCSB News

Conferences & Workshops

Fourth Annual “Host-Pathogen Interactions: Circuits to Systems” Symposium
Tuesday, February 6, 2018
8:30 am – 7:00 pm
Roth Auditorium at the Sanford Consortium for Regenerative Medicine
2880 Torrey Pines Science Drive, La Jolla, CA
Register for the event here

Winter q-Bio Meeting
February 22-25, 2018
Grand Wailea Resort, Maui
More info is available here

SDCSB’s Quarterly Systems-to-Synthesis Meeting (Spring 2018)
Thursday, May 17, 2018
2:00 – 5:00 pm
UC San Diego, Medical Education Telemedicine Bldg, 141-143
Registration begins spring 2018


Weekly Events

Genetics, Bioinformatics and Systems Biology Colloquium (2016-17)

qBio Seminar Series (2017-18)

Systems Biology Career Development Seminars (Spring 2017)

Monthly Events

San Diego Bioinformatics Users Series (SDBUS)

Systems Biology Club