Genetics, Bioinformatics and Systems Biology Colloquium
Thursdays, 12:00 pm – 1:00 pm
UC San Diego, Powell-Focht Bioengineering Hall, Fung Auditorium
Complete schedule here

Publications

Key Publications

  1. Liao, MJ, Din, MO, Tsimring, L, Hasty, J. Rock-paper-scissors: Engineered population dynamics increase genetic stability. Science. 2019;365 (6457):1045-1049. doi: 10.1126/science.aaw0542. PubMed PMID:31488693 .
  2. Lee, DD, Galera-Laporta, L, Bialecka-Fornal, M, Moon, EC, Shen, Z, Briggs, SP et al.. Magnesium Flux Modulates Ribosomes to Increase Bacterial Survival. Cell. 2019;177 (2):352-360.e13. doi: 10.1016/j.cell.2019.01.042. PubMed PMID:30853217 .
  3. Antonova-Koch, Y, Meister, S, Abraham, M, Luth, MR, Ottilie, S, Lukens, AK et al.. Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science. 2018;362 (6419):. doi: 10.1126/science.aat9446. PubMed PMID:30523084 PubMed Central PMC6516198.
  4. Martinez-Corral, R, Liu, J, Süel, GM, Garcia-Ojalvo, J. Bistable emergence of oscillations in growing Bacillus subtilis biofilms. Proc. Natl. Acad. Sci. U.S.A. 2018;115 (36):E8333-E8340. doi: 10.1073/pnas.1805004115. PubMed PMID:30127028 PubMed Central PMC6130386.
  5. Link, VM, Duttke, SH, Chun, HB, Holtman, IR, Westin, E, Hoeksema, MA et al.. Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function. Cell. 2018;173 (7):1796-1809.e17. doi: 10.1016/j.cell.2018.04.018. PubMed PMID:29779944 PubMed Central PMC6003872.
  6. Muse, ED, Yu, S, Edillor, CR, Tao, J, Spann, NJ, Troutman, TD et al.. Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. Proc. Natl. Acad. Sci. U.S.A. 2018;115 (20):E4680-E4689. doi: 10.1073/pnas.1714518115. PubMed PMID:29632203 PubMed Central PMC5960280.
  7. Zhang, W, Bojorquez-Gomez, A, Velez, DO, Xu, G, Sanchez, KS, Shen, JP et al.. A global transcriptional network connecting noncoding mutations to changes in tumor gene expression. Nat. Genet. 2018;50 (4):613-620. doi: 10.1038/s41588-018-0091-2. PubMed PMID:29610481 PubMed Central PMC5893414.
  8. Cowell, AN, Istvan, ES, Lukens, AK, Gomez-Lorenzo, MG, Vanaerschot, M, Sakata-Kato, T et al.. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science. 2018;359 (6372):191-199. doi: 10.1126/science.aan4472. PubMed PMID:29326268 PubMed Central PMC5925756.
  9. Li, Y, Jin, M, O'Laughlin, R, Bittihn, P, Tsimring, LS, Pillus, L et al.. Multigenerational silencing dynamics control cell aging. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (42):11253-11258. doi: 10.1073/pnas.1703379114. PubMed PMID:29073021 PubMed Central PMC5651738.
  10. Erickson, DW, Schink, SJ, Patsalo, V, Williamson, JR, Gerland, U, Hwa, T et al.. A global resource allocation strategy governs growth transition kinetics of Escherichia coli. Nature. 2017;551 (7678):119-123. doi: 10.1038/nature24299. PubMed PMID:29072300 PubMed Central PMC5901684.
  11. Dekker, J, Belmont, AS, Guttman, M, Leshyk, VO, Lis, JT, Lomvardas, S et al.. The 4D nucleome project. Nature. 2017;549 (7671):219-226. doi: 10.1038/nature23884. PubMed PMID:28905911 PubMed Central PMC5617335.
  12. Ou, HD, Phan, S, Deerinck, TJ, Thor, A, Ellisman, MH, O'Shea, CC et al.. ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells. Science. 2017;357 (6349):. doi: 10.1126/science.aag0025. PubMed PMID:28751582 PubMed Central PMC5646685.
  13. Gosselin, D, Skola, D, Coufal, NG, Holtman, IR, Schlachetzki, JCM, Sajti, E et al.. An environment-dependent transcriptional network specifies human microglia identity. Science. 2017;356 (6344):. doi: 10.1126/science.aal3222. PubMed PMID:28546318 PubMed Central PMC5858585.
  14. Diao, Y, Fang, R, Li, B, Meng, Z, Yu, J, Qiu, Y et al.. A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nat. Methods. 2017;14 (6):629-635. doi: 10.1038/nmeth.4264. PubMed PMID:28417999 PubMed Central PMC5490986.
  15. Liu, J, Martinez-Corral, R, Prindle, A, Lee, DD, Larkin, J, Gabalda-Sagarra, M et al.. Coupling between distant biofilms and emergence of nutrient time-sharing. Science. 2017;356 (6338):638-642. doi: 10.1126/science.aah4204. PubMed PMID:28386026 PubMed Central PMC5645014.
  16. Shen, JP, Zhao, D, Sasik, R, Luebeck, J, Birmingham, A, Bojorquez-Gomez, A et al.. Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. Nat. Methods. 2017;14 (6):573-576. doi: 10.1038/nmeth.4225. PubMed PMID:28319113 PubMed Central PMC5449203.
  17. Humphries, J, Xiong, L, Liu, J, Prindle, A, Yuan, F, Arjes, HA et al.. Species-Independent Attraction to Biofilms through Electrical Signaling. Cell. 2017;168 (1-2):200-209.e12. doi: 10.1016/j.cell.2016.12.014. PubMed PMID:28086091 PubMed Central PMC5497501.
  18. Cremer, J, Segota, I, Yang, CY, Arnoldini, M, Sauls, JT, Zhang, Z et al.. Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel. Proc. Natl. Acad. Sci. U.S.A. 2016;113 (41):11414-11419. doi: 10.1073/pnas.1601306113. PubMed PMID:27681630 PubMed Central PMC5068270.
  19. Harper, JW, Bennett, EJ. Proteome complexity and the forces that drive proteome imbalance. Nature. 2016;537 (7620):328-38. doi: 10.1038/nature19947. PubMed PMID:27629639 PubMed Central PMC5204264.
  20. Din, MO, Danino, T, Prindle, A, Skalak, M, Selimkhanov, J, Allen, K et al.. Synchronized cycles of bacterial lysis for in vivo delivery. Nature. 2016;536 (7614):81-85. doi: 10.1038/nature18930. PubMed PMID:27437587 PubMed Central PMC5048415.
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Recent Publications

  1. Liao, MJ, Din, MO, Tsimring, L, Hasty, J. Rock-paper-scissors: Engineered population dynamics increase genetic stability. Science. 2019;365 (6457):1045-1049. doi: 10.1126/science.aaw0542. PubMed PMID:31488693 .
  2. Castro, A, Ozturk, K, Pyke, RM, Xian, S, Zanetti, M, Carter, H et al.. Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes. BMC Med Genomics. 2019;12 (Suppl 6):107. doi: 10.1186/s12920-019-0544-1. PubMed PMID:31345234 PubMed Central PMC6657029.
  3. Martinez-Corral, R, Liu, J, Prindle, A, Süel, GM, Garcia-Ojalvo, J. Metabolic basis of brain-like electrical signalling in bacterial communities. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2019;374 (1774):20180382. doi: 10.1098/rstb.2018.0382. PubMed PMID:31006362 PubMed Central PMC6553584.
  4. Lee, DD, Galera-Laporta, L, Bialecka-Fornal, M, Moon, EC, Shen, Z, Briggs, SP et al.. Magnesium Flux Modulates Ribosomes to Increase Bacterial Survival. Cell. 2019;177 (2):352-360.e13. doi: 10.1016/j.cell.2019.01.042. PubMed PMID:30853217 .
  5. Jin, M, Li, Y, O'Laughlin, R, Bittihn, P, Pillus, L, Tsimring, LS et al.. Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics. Cell Syst. 2019;8 (3):242-253.e3. doi: 10.1016/j.cels.2019.02.002. PubMed PMID:30852250 PubMed Central PMC6514117.
  6. Fonseca, GJ, Tao, J, Westin, EM, Duttke, SH, Spann, NJ, Strid, T et al.. Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages. Nat Commun. 2019;10 (1):414. doi: 10.1038/s41467-018-08236-0. PubMed PMID:30679424 PubMed Central PMC6345992.
  7. Antonova-Koch, Y, Meister, S, Abraham, M, Luth, MR, Ottilie, S, Lukens, AK et al.. Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science. 2018;362 (6419):. doi: 10.1126/science.aat9446. PubMed PMID:30523084 PubMed Central PMC6516198.
  8. Winzeler, EA. An improbable journey: Creativity helped me make the transition from art to curing malaria. J. Biol. Chem. 2019;294 (2):405-409. doi: 10.1074/jbc.AW118.005229. PubMed PMID:30401750 PubMed Central PMC6333892.
  9. Cooper, R, Tsimring, L, Hasty, J. Microfluidics-Based Analysis of Contact-dependent Bacterial Interactions. Bio Protoc. 2018;8 (16):. doi: 10.21769/BioProtoc.2970. PubMed PMID:30370317 PubMed Central PMC6200413.
  10. Hoeksema, MA, Glass, CK. Nature and nurture of tissue-specific macrophage phenotypes. Atherosclerosis. 2019;281 :159-167. doi: 10.1016/j.atherosclerosis.2018.10.005. PubMed PMID:30343819 PubMed Central PMC6399046.
  11. Davis-Turak, J, Johnson, TL, Hoffmann, A. Mathematical modeling identifies potential gene structure determinants of co-transcriptional control of alternative pre-mRNA splicing. Nucleic Acids Res. 2018;46 (20):10598-10607. doi: 10.1093/nar/gky870. PubMed PMID:30272246 PubMed Central PMC6237756.
  12. Eckhardt, M, Zhang, W, Gross, AM, Von Dollen, J, Johnson, JR, Franks-Skiba, KE et al.. Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network. Cancer Discov. 2018;8 (11):1474-1489. doi: 10.1158/2159-8290.CD-17-1018. PubMed PMID:30209081 PubMed Central PMC6375299.
  13. Martinez-Corral, R, Liu, J, Süel, GM, Garcia-Ojalvo, J. Bistable emergence of oscillations in growing Bacillus subtilis biofilms. Proc. Natl. Acad. Sci. U.S.A. 2018;115 (36):E8333-E8340. doi: 10.1073/pnas.1805004115. PubMed PMID:30127028 PubMed Central PMC6130386.
  14. Larkin, JW, Zhai, X, Kikuchi, K, Redford, SE, Prindle, A, Liu, J et al.. Signal Percolation within a Bacterial Community. Cell Syst. 2018;7 (2):137-145.e3. doi: 10.1016/j.cels.2018.06.005. PubMed PMID:30056004 PubMed Central PMC6214369.
  15. Zarrinpar, A, Chaix, A, Xu, ZZ, Chang, MW, Marotz, CA, Saghatelian, A et al.. Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat Commun. 2018;9 (1):2872. doi: 10.1038/s41467-018-05336-9. PubMed PMID:30030441 PubMed Central PMC6054678.
  16. Zhou, Y, Xu, Z, Quan, D, Zhang, F, Zhang, H, Xiao, T et al.. Nuclear respiratory factor 1 promotes spheroid survival and mesenchymal transition in mammary epithelial cells. Oncogene. 2018;37 (47):6152-6165. doi: 10.1038/s41388-018-0349-2. PubMed PMID:29995872 PubMed Central PMC6329670.
  17. Cowell, AN, Valdivia, HO, Bishop, DK, Winzeler, EA. Exploration of Plasmodium vivax transmission dynamics and recurrent infections in the Peruvian Amazon using whole genome sequencing. Genome Med. 2018;10 (1):52. doi: 10.1186/s13073-018-0563-0. PubMed PMID:29973248 PubMed Central PMC6032790.
  18. Zhang, W, Ma, J, Ideker, T. Classifying tumors by supervised network propagation. Bioinformatics. 2018;34 (13):i484-i493. doi: 10.1093/bioinformatics/bty247. PubMed PMID:29949979 PubMed Central PMC6022559.
  19. Ozturk, K, Dow, M, Carlin, DE, Bejar, R, Carter, H. The Emerging Potential for Network Analysis to Inform Precision Cancer Medicine. J. Mol. Biol. 2018;430 (18 Pt A):2875-2899. doi: 10.1016/j.jmb.2018.06.016. PubMed PMID:29908887 PubMed Central PMC6097914.
  20. Link, VM, Romanoski, CE, Metzler, D, Glass, CK. MMARGE: Motif Mutation Analysis for Regulatory Genomic Elements. Nucleic Acids Res. 2018;46 (14):7006-7021. doi: 10.1093/nar/gky491. PubMed PMID:29893919 PubMed Central PMC6101580.
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A complete list of all our publications can be found here on PubMed