SDCSB began in 2005 as the San Diego Consortium for Systems Biology to bring together scientists across disciplines and institutions, promote collaborative research and training, and to support the exchange of ideas and resources.

NCSB LogoIn 2010, we became one of the National Centers for Systems Biology funded by the National Institute of General Medical Sciences (NIGMS) (Grant #GM085764). SDCSB comprises activities in (i) scientific research, (ii) scientific outreach, and (iii) educational outreach.

We welcome you to participate in the revolution that is gripping the biological and biomedical sciences, catalyzed by unprecedented measurement capabilities and computational analysis and modeling tools. Start by exploring this website, participate in our workshops, symposia and research meetings, and let us know about good ideas for new research and outreach activities that SDCSB can support.

Pulsing Signals Help to Overcome Noise

Pulsing Signals crop BBiological systems must transmit information in the face of both intrinsic noise inherent to biochemical reactions and extrinsic noise due to cell-to-cell variations. Using both experimental and theoretical approaches to, researchers in Roy Wollman’s group found that pulsed signals are more reliable at overcoming the effects of cell-to-cell variability that than just a single, one-off signal. 

Read in Science
Mutations in p53 Alone Don’t Explain Deadly Cancer

TP53-3p Survival Curves 2

Although mutations in p53 are associated with more aggressive forms of cancer, researchers in Trey Ideker’s lab have found evidence suggesting that the deleterious effects of the mutated gene may in large part be due to other genetic abnormalities, at least in squamous cell head and neck cancers. In a study published in Nature Genetics,  researchers found that the high mortality rates among head and neck cancer patients tends only to occur when mutations in p53 coincide with the loss of the short arm of chromosome 3.

Read in Nature Genetics
Using gene position to test the “histone code”

ideker2012In a novel use of gene knockout technology, researchers at the University of California, San Diego School of Medicine tested the same gene inserted into 90 different locations in a yeast chromosome – and discovered that while the inserted gene never altered its surrounding chromatin landscape, differences in that immediate landscape measurably affected gene activity.

Read in Cell Reports (2013)

Cytoscape and Network Analysis Workshop

March 25, 2015

Friday, April 17, 2015 from 8 am – 4 pm Main Auditorium at the Sanford Consortium for Regenerative Medicine Organized by Barry Demchak and Jason Kreisberg

Network analysis has become an increasingly common approach for tackling complicated, large data sets. In the morning, ...

Intellectual Property and Licensing Workshop

March 19, 2015

Friday, April 24, 2015 from 8 am – 6 pm Main Auditorium at the Sanford Consortium for Regenerative Medicine Organized by Kamala Janiyani

This workshop will bring together intellectual property professionals, entrepreneurs, researchers and students to discuss the recent developments in the area ...

Registration Open for the Network of BioThings Hackathon

The SDCSB is pleased to support the upcoming 1st BD2K 3rd Network of BioThings Hackathon. Hosted by Dr. Andrew Su‘s team at TSRI, the purpose of this hackathon is to bring together experts in their respective fields to work collectively ...

Previous SDCSB News

Conferences and Workshops

Systems-to-Synthesis Quarterly Research Meetings
April 10, 2015
The Village 15th Floor
Cytoscape and Network Analysis Workshop
April 17, 2015
Sanford Consortium for Regenerative Medicine
Organized by Barry Demchak & Jason Kreisberg
Click here to register
Math Modeling Tutorial Workshop
April 20, 2015 - April 25, 2015
UCSD Bonner Hall (Room 2130)
Organized by Lev Tsimring
Click here to register
Intellectual Property and Licensing Workshop
April 24, 2015
Sanford Consortium for Regenerative Medicine
Organized by Kamala Janiyani
Click here to register
Network of BioThings Hackathon
May 7, 2015 - May 10, 2015
The Scripps Research Institute
Click here to register

Weekly Events

Genetics, Bioinformatics and Systems Biology Colloquium (2014-15)

Joint BCI / SDCSB Seminar Series (2014 Fall)

Greatest Hits of Systems Biology Journal Club (2014 Winter)