SDCSB began in 2005 as the San Diego Consortium for Systems Biology to bring together scientists across disciplines and institutions, to promote collaborative research and training, and to support the exchange of ideas and resources.

NCSB LogoIn 2010, we became one of the National Centers for Systems Biology funded by the National Institute of General Medical Sciences (NIGMS) (P50 GM085764). Over the past five years our research has led to significant systems biology advances, including genome-wide studies of how stress remodels transcriptional and genetic networks, discovery of an independent metabolic clock coordinating cell growth through cycles of TOR1 activity, demonstration that much of the Gene Ontology can be inferred directly from ‘omics data, prediction of cancer survival time and drug response by an approach called Network Based Stratification and a series of major feats in engineering of synthetic coupled genetic circuits.

The theme of our Center – “From Maps to Models” – addresses an important challenge in systems biology: traversing between network maps and mathematical models, two very successful but so far mostly separate biological representations and modes of study. Network maps tend to be global, static, abstract and descriptive, whereas mathematical models tend to be local, dynamic, detailed and predictive. Guided by this overarching theme, four SDCSB research projects seek to develop a general library of maps and models relevant to fundamental cellular and super-cellular processes, including the spatiotemporal architecture of the genome, protein turnover dynamics, cell-cell communication and heterogeneity and environment-genome interactions. These mapping and modeling activities are fueled by technologies advanced across three SDCSB core platforms.

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Electricity Coursing through Biofilms

The endogenous role of ion channels in bacteria has long been a mystery. Recent work from the Suel lab has revealed that ion channels allow for long-range electrical communication in bacterial biofilms. These electrical signals play a key role coordinating growth. Perhaps then one way to control the growth of these largely antibiotic resistant biofilms is to disrupt these signals leading to unregulated growth and the eventual collapse of the entire community.

Read in Nature
PQBP1 triggers innate immue responses to HIV-1

The innate immune response to HIV-1 is in part coordinated by dendritic cells, immune sentinels that themselves are targets of HIV-1 infection. Sumit Chanda’s lab recently discovered that immunogenic HIV-1 reverse transcripts are recognized in dendritic cells by PQBP1, which then initiates the innate immune response.

Read in Cell

Pulsing Signals Help to Overcome Noise

Pulsing Signals crop BBiological systems must transmit information in the face of both intrinsic noise inherent to biochemical reactions and extrinsic noise due to cell-to-cell variations. Using both experimental and theoretical approaches to, researchers in Roy Wollman’s group found that pulsed signals are more reliable at overcoming the effects of cell-to-cell variability that than just a single, one-off signal. 

Read in Science

Cells, Sensors and Systems Symposium

September 23, 2015

Thursday, October 22, 2015, from 10 am to 5 pm Sanford Consortium For Regenerative Medicine

Co-Chairs: Jeffrey H. Price (SBP and Scintillon Institute) and John P. Nolan (Scintillon Institute) Chair Emeritus and Program Advisor: Robert F. Murphy (Carnegie Mellon University)

Program Committee: Mark Mercola ...

Curt Becker, Founder of Applied Biosystems, at the Fleet Center’s Suds and Science

September 8, 2015

As part of the Fleet Science Center’s Suds and Science Program, Curt Becker will present “Genetic Engineering—Can It Be the Solution to the World’s Problems?”

September 14, 2014, from 6:30 p.m. to about 8 p.m.

Stone Brewing World Bistro & Gardens – ...

Winter q-Bio Meeting

September 1, 2015

The Winter q-bio meeting welcomes scientists and engineers who are interested in all areas of q-bio. For 2016, the meeting will be held on the island of Oahu, at the Sheraton Waikiki, from February 14-18. More information can be found at ...
Previous SDCSB News

Conferences & Workshops

Host-Pathogen Interactions: Circuits to Systems
January 4, 2016 @ 9:00 am – 5:00 pm
Sanford Burnham Prebys Medical Discovery Institute
Register for the event here

Annual Scientific Retreat
January 29 – 31, 2016
UCLA Lake Arrowhead Conference Center
Click here for more information

Metabolomics Conference
February 19, 2016 @ 1:30 pm – 6:00 pm
Sanford Burnham Prebys Medical Discovery Institute
Organized by Asst. Prof. Mohit Jain, UCSD
Registration begins in late 2015

Math Modeling Tutorial Workshop
March 21 – 25, 2016
Organized by Dr. Lev Tsimring, UCSD
Registration begins in early 2016

Intellectual Property and Licensing Workshop
Sanford Burnham Prebys Medical Discovery Institute
Organized by Kamala Janiyani, UCSD
Registration begins in early 2016

Quarterly Systems-to-Synthesis Meeting
Meeting Rooms on Fifteen, Building 1, Village West
Registration begins in early 2016

Cytoscape Workshop
Sanford Burnham Prebys Medical Discovery Institute
Organized by Dr. Barry Demchak, UCSD
Registration begins in early 2016

Weekly Events

Genetics, Bioinformatics and Systems Biology Colloquium (2015-16)

qBio Seminar Series (2015 Fall)

Greatest Hits of Systems Biology Journal Club (2014 Winter)