Genetics, Bioinformatics and Systems Biology Colloquium
Thursdays, 12:00 pm – 1:00 pm
UC San Diego, Powell-Focht Bioengineering Hall, Fung Auditorium
Complete schedule here
6/1/12 Drug Discovery
Friday, June 1st 2012 – 8:00AM-5:00PM
The Salk Institute, Frederic de Hoffman Auditorium
Description
Drug discovery and development is recognized to be one of the most complex and risky endeavors undertaken by mankind. Recent evaluations of the drug industry and productivity over the last 10 years has shown that the average cost of each new drug reaching the market now exceeds 1 billion dollar and takes over a decade. While much has been written from a business perspective about the process and alternative approaches to succeed against the odds, there are many practical aspects to drug discovery that should be taken in to consideration before launching in to a translational program centered around a break through discovery made in the lab.This workshop will feature speakers from San Diego from both academia and industry who have first hand experience in managing successful drug discovery projects and navigating the parallel process of partnering and resourcing. It is intended to provide a forum for sharing experiences on the many components of drug discovery from technical consideration on the technology platform (small and large molecule) and the many steps of how drug candidates are identified, optimized and refined for use in the clinic. Projects at all stages of the process (assay development, high-throughput screening, hit to lead, lead optimization through preclinical to a drug candidate) will be highlighted with specific examples of successful projects that resulted in clinical candidates and drugs. Practical considerations of how to source the multi-disciplinary activities needed to execute a drug discovery and preclinical program will be discussed. Options of how to fund a drug discovery program (grants, contracts, collaborations, VC, etc) will be identified, along with insight into how and when to secure intellectual property, how and when to partner a project and many other aspects of business development. ***Participation is FREE.***Confirmed Speakers:
Micah J. Niphakis, Ph.D. (The Scripps Research Institute)
Stephen L. Gwaltney, II, Ph.D. (Takeda California)
Véronique Plantevin Krenitsky, Ph.D. (Celgene)
Kevin Lustig, Ph.D. (Assay Depot)
Anne Bang. Ph.D. (Sanford-Burnham Medical Research Institute)
Peppi Prasit, Ph.D. (Inception Sciences)
M. Wainwright Fishburn, Jr. (Cooley LLP)
Ed Ainscow, Ph.D. (Genomics Institute of the Novartis Research Foundation)
Scott Glaser, Ph.D. (Pfizer CTI)
J. Eric McDuffie, MBA, Ph.D. (Janssen Research & Development LLC)
Trevor Collingwood, Ph.D. (Sigma Aldrich)
TC Chung (Sanford-Burnham Medical Research Institute)
***Workshop Organizer: Michael Jackson (Sanford-Burnham Medical Research Institute)***
Program
**CLICK HERE for Printer Friendly Schedule**
8:00-8:45AM – Registration/Light Refreshments
8:45-9:00AM – Welcome Remarks
Michael Jackson, PhD, Vice President Drug Discovery and Development
Sanford-Burnham Medical Research Institute
9:00-9:30AM – Micah J. Niphakis, Ph.D. The Scripps Research Institute (Ben Cravatt’s Lab)
“Applications of Activity-based Protein Profiling in the Development of Endocannabinoid Hydrolase Inhibitors“
9:30-10:00AM – Stephen L. Gwaltney, II, Ph.D. Director of Chemistry, Takeda
“Using Structural Information to Accelerate Drug Discovery: The Takeda Dipeptidyl Peptidase-4 Program“
10:00-10:25AM – Kevin Lustig, Ph.D. CEO, Assay Depot
“Research Exchanges: Bringing the Best of the Web to Science“
10:25AM COFFEE BREAK
10:45-11:15AM – Anne Bang, Ph.D., Director Cell Biology
Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute
“Patient specific cell based disease models for drug discovery“
11:15-11:45AM – Ed Ainscow, Ph.D. Genomics Institute of the Novartis Research Institute
“High throughput phenotypic screening: Embracing biological complexity“
11:45AM-12:10PM – Trevor Collingwood, Ph.D. Sigma Aldrich
“Cellular Models & Assays – The application of CompoZr ZFN Technology”
12:10PM FREE LUNCH for first 200 registered attendees
1:30-2:00PM – Scott Glaser, Ph.D. Pfizer CTI
“Therapeutic Antibodies- Trends in Discovery Research“
2:00-2:30PM – Véronique Plantevin Krenitsky, Ph.D. Principal Scientist, Celgene
“Discovery of CC-930, an Orally Active Anti-fibrotic JNK Inhibitor“
2:30-2:55PM – J. Eric McDuffie, MBA, Ph.D., JanssenResearch & Development LLC
“Use of Renal Biomarkers in Drug Development“
2:55PM COFFEE BREAK
3:15-3:35PM – Thomas “TC” Chung, Ph.D., Director Outreach
Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute
“NIH Funding opportunities for drug discovery“
3:35-4:05PM – Peppi Prasit, Ph.D., CEO, Inception Sciences
“Biotech 2.0“
4:05-4:35PM – M. Wainwright Fishburn, Jr. Cooley LLP
“The Art of Startup: Securing Intellectual Property and Turning it into a Business“
4:35PM – HOSTED RECEPTION
